Literature Review of Factors Affecting Premature Rupture of Membranes
DOI:
https://doi.org/10.70062/greenhealth.v2i4.246Keywords:
Antenatal Care, Nutritional Status, Obstetric Risk, Prelabor Rupture of Membranes, Reproductive InfectionsAbstract
Prelabor rupture of membranes (PROM) remains one of the most frequently encountered obstetric complications and continues to contribute substantially to maternal and neonatal morbidity and mortality. Numerous factors have been associated with PROM; however, the available evidence presents considerable variation, highlighting the need to re-evaluate these determinants using recent empirical findings. This review aims to identify and synthesize the principal factors influencing PROM based on ten studies published within the last five years. A systematic search was conducted across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords, followed by screening through established eligibility criteria. Relevant data from each study including study design, geographical setting, assessed risk factors, and statistical outcomes such as odds ratios or relative risks were extracted and compared. The review indicates that reproductive and urinary tract infections, inadequate nutritional status, high-risk obstetric history, and short interpregnancy intervals consistently emerge as major determinants. Social factors and the quality of antenatal services were also shown to heighten the likelihood of PROM. Overall, the findings emphasize that PROM arises from a combination of medical and non-medical influences, reinforcing the need for preventive strategies that adopt a comprehensive and integrated approach.
References
Argaw, M., Mesfin, Y., Geze, S., Nuriye, K., Tefera, B., Embiale, A., Mohammed, W., & Chekole, B. (2021). Preterm premature rupture of membranes and factors associated among pregnant women admitted in Wolkite Comprehensive Specialized Hospital, Gurage Zone, Southern Ethiopia. Infectious Diseases in Obstetrics and Gynecology, 2021, Article 3949260. https://doi.org/10.1155/2021/3949260
Dayal, S., Jenkins, S. M., & Hong, P. L. (2024). Preterm and term prelabor rupture of membranes (PPROM and PROM). In StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK532888/
Enjamo, M., Deribew, A., Semagn, S., & Mareg, M. (2022). Determinants of premature rupture of membrane (PROM) among pregnant women in Southern Ethiopia: A case-control study. International Journal of Women’s Health, 4(March), 455–466. https://doi.org/10.2147/IJWH.S352348
Getnet, A., Oljira, L., Assefa, N., Tiruye, G., & Figa, Z. (2023). Determinants of premature rupture of membrane among pregnant women in Harar Town, Eastern Ethiopia: A case-control study. Heliyon, 9(4), e15445. https://doi.org/10.1016/j.heliyon.2023.e15445
Granero, R., Icaza, D., & Maraver-Capdevila, L. (2025). Network study of the nutritional patterns, the metabolic and the psychological status among overweight-obese young adults. Frontiers in Nutrition, 19(September), 1666688. https://doi.org/10.3389/fnut.2025.1666688
Hossain, Z., Afroz, N., Sharmin, S., & Sharmin, E. K. S. (2023). Determinants of maternal morbidity during pregnancy in urban Bangladesh. PLOS ONE, 8(2), 1–11. https://doi.org/10.1371/journal.pone.0268487
Jena, B. H., Biks, G. A., & Gete, Y. K. (2022). Incidence of preterm premature rupture of membranes and its association with inter-pregnancy interval: A prospective cohort study. Scientific Reports, 12(5714), 1–8. https://doi.org/10.1038/s41598-022-09743-3
Kong, X., Jiang, L., Zhang, B., Sun, L., & Liu, K. (2023). Predicting chorioamnionitis in patients with preterm premature rupture of membranes using inflammatory indexes: A retrospective study. Taiwanese Journal of Obstetrics & Gynecology, 62(1), 112–118. https://doi.org/10.1016/j.tjog.2022.11.006
Lathifa, S. N., & Rahayuningsih, F. B. (2025). Factors associated with the incidence of premature rupture of membranes. Indonesian Journal of Global Health Research, 7(1), 833–848. https://doi.org/10.37287/ijghr.v7i1.5450
Li, Y., Cui, S., Shi, B. W., Zhang, Y., Yuan, Y., Yan, S., Li, Y., Xu, Y., & Zhang, Z. (2020). Differential placental methylation in preeclampsia, preterm, and term pregnancies. Placenta, 93, 56–63. https://doi.org/10.1016/j.placenta.2020.02.009
Lin, D., Hu, B., Xiu, Y., Ji, R., Zeng, H., Chen, H., & Wu, Y. (2024). Risk factors for premature rupture of membranes in pregnant women: A systematic review and meta-analysis. BMJ Open, 14, e077727. https://doi.org/10.1136/bmjopen-2023-077727
Lv, C., Lu, Q., Zhang, C., Wang, R., Son, X., Yan, S., Chen, H., Pan, X.-F., & Fu, C. (2024). Relationship between first trimester physical activity and premature rupture of membranes: A birth cohort study in Chinese women. BMC Public Health, 24, 1736. https://doi.org/10.1186/s12889-024-18791-5
Menon, R., Lappas, M., & Zakar, T. (2021). Editorial: The role of the fetal membranes in pregnancy and birth. Frontiers in Physiology, 12(February), 10–13. https://doi.org/10.3389/fphys.2021.653084
Parry, S., & Strauss, J. F. (1998). Premature rupture of the fetal membranes. The New England Journal of Medicine, 338(10), 681–686. https://doi.org/10.1056/NEJM199803053381006
Pecora, F., Persico, F., Argentiero, A., Neglia, C., & Esposito, S. (2020). The role of micronutrients in support of the immune response against viral infections. Nutrients, 12, 3198. https://doi.org/10.3390/nu12103198
Purnamawati, I. (2024). Risk factor for premature rupture of membranes: A clinical study. International Journal of Research in Medical Sciences, 12(5), 1462–1465. https://dx.doi.org/10.18203/2320-6012.ijrms20241228
Rokhila, S. A., & Sukarni, D. (2023). Factors associated with premature rupture of membrane. Jurnal Kebidanan Malahayat, 9(3), 363–368. https://doi.org/10.33024/jkm.v9i3.11011
Suriyadi, & Hendra. (2024). A systematic review of risk factors for premature rupture of membrane in pregnant women. The International Journal of Medical Science and Health Research.
Tadesse, S., Addisu, E., Wudu, M. A., & Belete, M. A. (2024). Determinants of premature membrane rupture among mothers receiving labor care at public hospitals in Northeast Ethiopia: An unmatched case-control study. Scientific Reports, 14(29811), 1–11. https://doi.org/10.1038/s41598-024-72971-2
Tiruye, G., Shiferaw, K., Tura, A. K., Debella, A., & Musa, A. (2021). Prevalence of premature rupture of membrane and its associated factors among pregnant women in Ethiopia: A systematic review and meta-analysis. SAGE Open Medicine, 9, 1–9. https://doi.org/10.1177/20503121211053912
Wu, T., Mu, D.-Z., Shi, J., Qu, S., & Yi, Y. (2017). Effect of premature rupture of membranes on maternal infections and outcomes of preterm infants. Chinese Journal of Contemporary Pediatrics, 19(8), 861–865. https://doi.org/10.7499/j.issn.1008-8830.2017.08.004
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Green Health International Journal of Health Sciences Nursing and Nutrition

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

