Dynamics of Anti-Diabetic Medication Adherence and the Influence of Side Effects: A Study on Patients with Type 2 Diabetes Mellitus in Bandung Regency and Bandung City
DOI:
https://doi.org/10.70062/globalhealth.v2i3.213Keywords:
Clinical Interventions, Drug Side Effects, Medication Adherence, Pharmacological Management, Type 2 Diabetes MellitusAbstract
Type 2 Diabetes Mellitus (T2DM) is a chronic condition that requires optimal adherence to pharmacological treatment to prevent disease progression and complications. This study aims to analyze the level of adherence to anti-diabetic medication among T2DM patients and to explore the association between the experience of medication side effects and adherence levels. A descriptive-analytic cross-sectional design was employed, involving 97 T2DM patients in Bandung Regency and Bandung City, Indonesia. Data were collected through structured questionnaires and analyzed using descriptive statistics and the Chi-Square test. The results revealed that 53.6% of respondents exhibited low medication adherence. The majority reported having diabetes-related complications (88.7%) and experiencing medication side effects (57.7%). A significant positive association was found between medication side effects and adherence level (p = 0.039), indicating that patients who experienced side effects tended to be more adherent. Demographic factors such as place of residence, gender, and age showed no significant association with adherence. The findings suggest that side effects may hinder adherence; however, awareness of the body’s response to medication, including side effects, may also serve as a motivator for adherence.
References
American Diabetes Association. (2017). Standards of Medical Care in Diabetes—2017 Abridged for Primary Care Providers. Clinical Diabetes, 35(1), 5–26. https://doi.org/10.2337/cd16-0067
Broadbent, E., Donkin, L., & Stroh, J. C. (2011). Illness and Treatment Perceptions Are Associated With Adherence to Medications, Diet, and Exercise in Diabetic Patients. Diabetes Care, 34(2), 338–340. https://doi.org/10.2337/dc10-1779
Chao, J., Nau, D. P., & Aikens, J. E. (2007). Patient-reported perceptions of side effects of antihyperglycemic medication and adherence to medication regimens in persons with diabetes mellitus. Clinical Therapeutics, 29(1), 177–180. https://doi.org/10.1016/j.clinthera.2007.01.014
Creswell, J. W., & Creswell, J. D. (2022). Research Design Qualitative, Quantitative, and Mixed Methods Approaches (6th edition). SAGE Publications. https://uk.sagepub.com/en-gb/eur/research-design/book270550
Dimore, A. L., Edosa, Z. K., & Mitiku, A. A. (2023). Glycemic control and diabetes complications among adult type 2 diabetic patients at public hospitals in Hadiya zone, Southern Ethiopia. PLOS ONE, 18(3), e0282962. https://doi.org/10.1371/journal.pone.0282962
Fajriansyah, F. (2022). Gambaran Tingkat Kepatuhan Minum Obat Pasien Diabetes Melitus Tipe 2 di Puskesmas Pertiwi Kota Makassar. Wal’afiat Hospital Journal, 3(2), 156–164. https://doi.org/10.33096/whj.v3i2.88
García-Pérez, L.-E., Álvarez, M., Dilla, T., Gil-Guillén, V., & Orozco-Beltrán, D. (2013). Adherence to Therapies in Patients with Type 2 Diabetes. Diabetes Therapy, 4(2), 175–194. https://doi.org/10.1007/s13300-013-0034-y
Gumilas, N. S. A., Harini, I. M., Samodro, P., & Ernawati, D. A. (2021). MMAS-8 SCORE ASSESSMENT OF THERAPY ADHERENCE TO GLYCEMIC CONTROL OF PATIENTS WITH TYPE 2 DIABETES MELLITUS, TANJUNG PURWOKERTO, JAVA, INDONESIA (OCTOBER 2018). The Southeast Asian Journal of Tropical Medicine and Public Health, 52(3), 359–370.
Haghighatpanah, M., Nejad, A. S. M., Haghighatpanah, M., Thunga, G., & Mallayasamy, S. (2018). Factors that Correlate with Poor Glycemic Control in Type 2 Diabetes Mellitus Patients with Complications. Osong Public Health and Research Perspectives, 9(4), 167–174. https://doi.org/10.24171/j.phrp.2018.9.4.05
Hestiana, D. W. (2017). Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Dalam Pengelolaan Diet Pada Pasien Rawat Jalan Diabetes Mellitus Tipe 2 Di Kota Semarang. Jurnal of Healt Education, 2(2), 138–145.
International Diabetes Federation (IDF). (2021). IDF Diabetes Atlas 10th edition. International Diabetes Federation.
Juwariah, T., & Priyanto, A. (2021). HUBUNGAN SELF CARE DENGAN KESTABILAN GULA DARAH PASIEN DIABETES MELLITUS TYPE II. Jurnal Ilmu Kesehatan, 10(1).
Kawa, A. B. E., Wiyono, W., & Mpila, D. (2022). EVALUASI TINGKAT KEPATUHAN MINUM OBAT ANTIDIABETES PADA PASIEN DIABETES MELITUS TIPE 2 RAWAT JALAN DI PUSKESMAS MINANGA MANADO. PHARMACON, 11(3). https://ejournal.unsrat.ac.id/v3/index.php/pharmacon/article/view/41239
Lim, M. C., Hatah, E., Lai, K. C., Buang, A., Koay, T. J., Sim, W. J. Y., & Ng, S. C. (2022). Perceptions with Type 2 Diabetes Mellitus of the Value of Prescribed Medications Among Malaysian Adults: A Qualitative Study. Patient Preference and Adherence, 16, 3133–3142. https://doi.org/10.2147/PPA.S382341
Richardson, C. R., Borgeson, J. R., Van Harrison, R., Wyckoff, J. A., Yoo, A. S., Aikens, J. E., Griauzde, D. H., Tincopa, M. A., Van Harrison, R., Proudlock, A. L., & Rew, K. T. (2021). Management of Type 2 Diabetes Mellitus. Michigan Medicine University of Michigan. http://www.ncbi.nlm.nih.gov/books/NBK579413/
Rif’at, I. D., N, Y. H., & Indriati, G. (2023). GAMBARAN KOMPLIKASI DIABETES MELITUS PADA PENDERITA DIABETES MELITUS. Jurnal Keperawatan Profesional, 11(1), 52–69. https://doi.org/10.33650/jkp.v11i1.5540
Rivan Virlando Suryadinata, Onny Priskila, & Adhimas Setyo Wicaksono. (2024). POPULASI DAN SAMPEL PENELITIAN KESEHATAN. Penerbitan & Publikasi Ilmiah (PPI) Universitas Surabaya. https://ppi.ubaya.ac.id/buku-terbitan/katalog-buku-ppi-ubaya/populasi-dan-sampel-penelitian-kesehatan/
Sims, T. J., Boye, K. S., Robinson, S., & Kennedy-Martin, T. (2022). Treatment-Related Attributes of Diabetes Therapies and How People with Type 2 Diabetes Report Their Impact on Indicators of Medication-Taking Behaviors. Patient preference and adherence, 16, 1919–1939. https://doi.org/10.2147/PPA.S367046
Srikartika, V. M., Cahya, A. D., & Hardiati, R. S. W. (2016). ANALISIS FAKTOR YANG MEMENGARUHI KEPATUHAN PENGGUNAAN OBAT PASIEN DIABETES MELITUS TIPE 2. Jurnal Manajemen dan Pelayanan Farmasi, 6(3).
Sugiyono. (2017). Metode penelitian kuantitatif, kualitatif, dan R&D. Alfabet.
Yulianto, Aditama, L., Kartini, K., & Pranoto, A. (2019). Pemantauan Efek Samping Obat Kombinasi Antidiabetes dan Fitofarmaka “X” Pada Pasien DM Tipe-2 di Komunitas. JURNAL FARMASI GALENIKA, 6(3), 187–201.
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